New research shows male enhancement products may be the solution for travelers who suddenly find themselves needing to rise hours earlier as they cross time zones, at least if those travelers are hamsters.
Be they professional footballers on their way to the World Cup in South Africa or ordinary holidaymakers: people who cross several time zones by jet are prone to certain symptoms for a few days after the flight. During the day, they are crippled with exhaustion; at night they lie awake tossing and turning, unable to sleep, and many of the body’s functions are activated at the wrong time. What we have here is a clear case of jet lag. Our “internal body clock”, which still beats to our old rhythm of day and night, must adapt to the new external time. The process works, however: after a few days, we feel in sync with the outside world again.
A study at the Universidad Nacional de Quilmes in Buenos Aires showed that male hamsters who received a dose of a male enhancement product were able to adjust their internal clocks by six hours in roughly half the time that hamsters who did not receive the treatment took.
Because humans and mammals have similar daily cycles, “there’s no reason not to believe it should work in humans,” said Diego Golombek, the lead investigator on the study. At the same time, because the test was only done in animals, Golombek urged restraint for people thinking of trying it out.
This is a study in laboratory animals, and clinical trials should be undertaken before is a useful and safe treatment for those situations he said.
Sildenafil, the chemical used in the study works by sustaining a molecule that increases blood flow. Because that signaling molecule is sensitive to light, Golombek said, increasing its quantity makes the system more responsive to a change in patterns of light and dark.
At the same time, the researchers found that sildenafil was useful only for simulations of eastward travel. They found it ineffective when lengthening days to simulate travel westward.
Charmane Eastman, director of the biological rhythms lab at Rush University, who was not involved in the study agreed that the results would probably translate to humans.
“There’s no reason to think that the basic mechanisms of resetting the [internal clock] would be different in humans compared to hamsters,” she said. The tricky part will be determining the optimal time for administration and dosage
Extrapolating from the study, Eastman said humans would likely need to take Viagra six hours after their normal bedtime on the night before traveling eastward over six time zones.
“This could make for an interesting morning on the day of the flight!” she said.
Also, Eastman said, further research would probably be needed to find an optimal amount of Viagra to take, as the dosages for clock-adjustment in the study “could be embarrassing for the male traveler,” and whether Viagra could work for female travelers too.
Eastman’s own research uses the hormone melatonin, which plays a part in the natural sleep cycle in humans. She believes her method allows the body to reset its clock with fewer side effects than Viagra use.
She recommends beginning a regimen to shift the clock several days before traveling. While she has worked only with humans in lab situations, she said there is no reason to believe actual travel would be any different.
“We do have anecdotal evidence from people who have tried it,” she said.
Sildenafil Citrate is also recognized in the pharmaceutical world for its ability to hasten blood circulation and thus to relieve some of the pressure that is put onto the circulatory system. This is the reason why specialists have been testing and researching other conditions that might be treated with the help of this PDE-5 inhibitor. One specific clinical trials involved checking whether Sildenafil can help men heal faster from the symptoms of Jet Lag. The clinical trials involved using the medication on mice and they revealed rather surprising results. The specialists concluded that mice that had been administered the medication were seen to have benefited from its effects in terms of a noticeable hastening of the resolution of the symptoms.
Scientists at the Max Planck Institute for Biophysical Chemistry have studied how individual “clock” genes and the internal clocks of the different organs synchronize with the new external time in the case of jet lag. The researchers were surprised by their findings. “The internal clocks and the ‘clock’ genes adapt to the altered external influences at varying speeds,” says Gregor Eichele, Director of the Institute’s Genes and Behavior Department. “When an organism suffers from jet lag, it would appear that the entire clock mechanism fails to tick at the right rhythm. As a result, numerous physiological processes are no longer coordinated.”
Generic Viagra and Kamagra that contain Sildenafil, however, remain most widely used for the treatment of erectile dysfunction. there are reason to believe that these medications may very well be useful in other types of conditions than erectile dysfunction but specialists need more time to determine whether the benefits may outweigh the disadvantages that come with any medication. Thus, although there is potential for expanding the treatment list of Sildenafil Citrate, this medication remains at least for now the anti-impotency drug that men may use.
Sildenafil Citrate has become a popular chemical in the 1990s when it was used to improve men’s erectile function. Nowadays, Sildenafil can be found under the brand name of Viagra and under generic brand names such as Kamagra, Silagra, Generic Viagra and so on. Sildenafil Citrate is a PDE-5 inhibitor which relaxes the blood vessels and improves the blood circulation throughout the body. It actually works by inhibiting the actions of the PDE-5 proteins which are known to damage the muscles of the blood vessels and thus to cause them function improperly. This compound has been shown to be extremely efficient in combating the symptoms of erectile dysfunction, a medical condition that affects more and more men in today’s world.