Prescription Drugs


Your penis requires blood to become erect.  Plain and simple.  Prescription and over the counter male enhancements all have ingredients designed to improve, increase, and stimulate blood flow to the penis.  Each ingredient works in different ways and target a different part of the process.

One of the key ways this is done is focusing on PDE5 and nitric oxide.  Such drugs inhibit PDE5 and enhance the effects of nitric oxide improving blood flow and relaxing muscles in the penis. This increases blood flow and relaxed muscles allows you to get an erection in response to sexual stimulation.

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There are three common and popular medications on the market:

All three medications work in much the same way. Sildenafil was developed as a heart medication (history).  They inhibit PDE5 resulting in the increase of nitric oxide.  These medications vary in dosage, how long they work and their side effects.  Of the three drugs, Cialis (Tadalafil) has the longest half-life which means it lasts longest in your body but also takes longer to start to work.

Avanafil  approved by the FDA in 2012 is the newest ED drug to win approval works quickly, studies show that most men will be able to have an erection in as little as 15 minutes.  Avanafil is marked as Stendra by Vivus.   Sildenafil (Viagra)  and Vardenafil (Levitra) works in 30 – 60 minutes, while Tadalafil (Cialis) take even longer.

Endurnz Male Enhancement

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The also have serious and potentially deadly side effects.  This is why many men have turned to natural over the counter herbal cures.  Natural alternatives are also much much cheaper and do not require an expensive trip to the doctors and tests.

Men who have erectile dysfunction may be eager to solve that specific problem, but a new study adds to a growing body of evidence suggesting that erectile dysfunction may be a sign of other health problems.

Researchers found 2,200 deaths linked to prescription erectile dysfunction (ED) drugs, based on reports to the Food and Drug Administration’s (FDA) Office of Surveillance and Epidemiology from 2000 to 2010.  Avanafil is thought to have lower side effects than other drugs in its class.

In addition to the 3 popular oral pills there are other doctor prescribed options:

  • Alprostadil self-injection. With this method, you use a fine needle to inject alprostadil (Alprostadil, Caverject Impulse, Edex) into the base or side of your penis. In some cases, medications generally used for other conditions are used for penile injections on their own or in combination. Examples include papaverine, alprostadil and phentolamine. Each injection generally produces an erection in five to 20 minutes that lasts about an hour. Because the needle used is very fine, pain from the injection site is usually minor. Side effects can include bleeding from the injection, prolonged erection and formation of fibrous tissue at the injection site.
  • Alprostadil penis suppository. Alprostadil intraurethral (MUSE) therapy involves placing a tiny alprostadil suppository inside your penis. You use a special applicator to insert the suppository about two inches down into your penis. Side effects can include pain, minor bleeding in the urethra, dizziness and formation of fibrous tissue inside your penis.
  • Testosterone replacement. Some men have erectile dysfunction caused by low levels of the hormone testosterone, and may need testosterone replacement therapy.

Penis pumps, surgery and implants

Some men do not respond the medication.  For them there are more invasive options:

  • Penis pumps. A penis pump (vacuum constriction device) is a hollow tube with a hand-powered or battery-powered pump. The tube is placed over your penis, and then the pump is used to suck out the air inside the tube. This creates a vacuum that pulls blood into your penis. Once you get an erection, you slip a tension ring around the base of your penis to hold in the blood and keep it firm. You then remove the vacuum device. The erection typically lasts long enough for a couple to have sex. You remove the tension ring after intercourse.
  • Penile implants. This treatment involves surgically placing devices into the two sides of the penis. These implants consist of either inflatable or semirigid rods made from silicone or polyurethane. The inflatable devices allow you to control when and how long you have an erection. The semirigid rods keep the penis firm but bendable. This treatment can be expensive and is usually not recommended until other methods have been tried first. As with any surgery, there is a risk of complications such as infection.
  • Blood vessel surgery. In rare cases, a leaking blood vessel can cause erectile dysfunction and surgery is necessary to repair it.

Natural Alternatives

The market is flooded with natural supplements for erectile dysfunction and male enhancement. The ingredients are regulated by the FDA and do not require a prescription or doctor’s visit. Three of the most popular are Endurnz, Enzyte and Extenze.  They are backed by agressive marketing plans and contain natural plant extracts, herbs, vitamins, minerals and amino acids.  The extracts and herbs have been used in traditional medicines for centuries and are considered safe.  The minerals, vitamins and amino acids have been linked to improved blood circulation, boosting testosterone, increased muscle control, and stamina. Many of the ingredients have natural properties that work similar to the prescription compounds by effecting smooth muscles, blood flow, and nitric oxide production.

Your prescription can give you erectile dysfunction

Many common prescription medication can cause erectile dysfunction. If you are taking any of these and have problems achieving or maintain a erection see your doctor, right away.

Diuretics and high blood pressure drugs

  1. Hydrochlorothiazide (Esidrix, HydroDIURIL, Hydropres, Inderide, Moduretic, Oretic, Lotensin)
  2. Chlorthalidone (Hygroton)
  3. Triamterene (Maxide, Dyazide)
  4. Furosemide (Lasix)
  5. Bumetanide (Bumex)
  6. Guanfacine (Tenex)
  7. Methyldopa (Aldomet)
  8. Clonidine (Catapres) Verapamil (Calan, Isoptin, Verelan) Nifedipine (Adalat, Procardia)
  9. Hydralazine (Apresoline)
  10. Captopril (Capoten)
  11. Enalapril (Vasotec)
  12. Metoprolol (Lopressor),
  13. Propranolol (Inderal)
  14. Labetalol (Normodyne)
  15. Atenolol (Tenormin)
  16. Phenoxybenzamine (Dibenzyline)
  17. Spironolactone (Aldactone)

Antidepressants, anti-anxiety drugs, and antiepileptic drugs

  1. Fluoxetine(Prozac)
  2. Tranylcypromine (Parnate)
  3. Sertraline (Zoloft)
  4. Isocarboxazid (Marplan)
  5. Amitriptyline (Elavil)
  6. Amoxipine (Asendin)
  7. Clomipramine (Anafranil)
  8. Desipramine (Norpramin)
  9. Nortriptyline (Pamelor)
  10. Phenelzine (Nardil)
  11. Buspirone (Buspar)
  12. Chlordiazepoxide (Librium)
  13. Clorazepate (Tranxene)
  14. Diazepam (Valium)
  15. Doxepin (Sinequan)
  16. Imipramine (Tofranil)
  17. Lorazepam (Ativan)
  18. Oxazepam(Serax)
  19. Phenytoin(Dilantin)


  1. Dimehydrinate (Dramamine)
  2. Diphenhydramine (Benadryl)
  3. Hydroxyzine (Vistaril)
  4. Meclizine (Antivert)
  5. Promethazine (Phenergan)

Non-steroidal anti-inflammatory drugs

  1. Naproxen (Anaprox, Naprelan, Naprosyn)
  2. Indomethacin (Indocin)

Parkinson’s disease medications

  1. Biperiden (Akineton)
  2. Benztropine (Cogentin
  3. Trihexyphenidyl (Artane)
  4. Procyclidine (Kemadrin)
  5. Bromocriptine (Parlodel)
  6. Levodopa (Sinemet)


Disopyramide (Norpace)

Histamine H2-receptor antagonists

  1. Cimetidine (Tagamet)
  2. Nizatidine (Axid)
  3. Ranitidine (Zantac)

Muscle relaxants

  1. Cyclobenzaprine (Flexeril)
  2. Orphenadrine (Norflex)

Prostate cancer medications

  1. Flutamide (Eulexin)
  2. Leuprolide (Lupron)

Chemotherapy drugs

  1. Busulfan (Myleran)
  2. Cyclophosphamide (Cytoxan)

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