Viagra may cure Multiple sclerosis

Pharma giant Pfizer may soon may be cranking out even more little blue pills if the results from a recent study in Spain hold up. Sildenafil, the active ingredient in Viagra, may soon get a clinical trial for treating multiple sclerosis (MS) in humans thanks to an animal model study that demonstrated a practically complete recovery in 50 percent of the animals after eight days of treatment. The study, by researchers at Universitat Autònoma de Barcelona, appears in Acta Neuropathologica.  Spanish university researchers have discovered that popular ED medicine Viagra®  (sildenafil) can drastically reduces multiple sclerosis symptoms in animal with this disease.  The scientests are confident that clinical trials soon will be carried out in patients given that the drug is used by millions and has been used to treat sexual dysfunction in some multiple sclerosis patients.

Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system and one of the main causes of disability among young adults. Multiple sclerosis (MS) affects women more than men. The disorder is most commonly diagnosed between ages 20 and 40, but can be seen at any age. MS is caused by damage to the myelin sheath, the protective covering that surrounds nerve cells. When this nerve covering is damaged, nerve signals slow down or stop. The nerve damage is caused by inflammation. Inflammation occurs when the body’s own immune cells attack the nervous system. This can occur along any area of the brain, optic nerve, and spinal cord. It is unknown what exactly causes this to happen. The most common thought is that a virus or gene defect, or both, are to blame. Environmental factors may play a role.

Sidenafil, together with tadalafil (Cialis®) and vardenafil (Levitra®), form part of a group of vasodilator drugs known as phosphodiesterase type 5 (PDE5) inhibitors, used in the treatment of erectile dysfunction and pulmonary arterial hypertension. Recent studies in animal models of central nervous system pathologies already pointed to the fact that in addition to vasodilation, these drugs could contain other neuroprotective actions and suggest their usefulness as possible treatments of both acute (cerebrovascular stroke) and chronic (Alzheimer’s) neuropathologies.

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